Study of the hypoglicemic activity of the tea of the wood of Quassia-do-Brasil, Picrasma crenata (Vell.) Engl. in mice and rats
DOI:
https://doi.org/10.3395/2317-269x.00234Keywords:
Hypoglycemic activity, diabetes mellitus, Quássia-do-Brasil, glucose overloading, intestinal perfusionAbstract
The hypoglycemic activity of tea made from the wood of Quássia-do-Brasil [Picrasma crenata (Vell.) Engl.] was studied by assessment of glycemia in normoglycemic animals. The tea was given in concentrations of 5%, 10%, and 20%, with the concentration of 10% proving to be most effective. The 10% concentration promoted a decrease of glycemic levels in diabetic animals who were given streptozotocin (65 mg/kg) and in hyperglycemic animals who received an overloading glucose solution of 25% via intravenous administration Propranolol (10 mg/kg, intraperitoneal), a non-specific adrenergic β-blocker, did not affect the activity of the tea in normal or hyperglycemic animals. The tea of Quássia-do-Brasil was able to inhibit intestinal absorption of glucose as well as its reabsorption from the renal glomerulus. The hypoglycemic mechanism of the tea does not appear to involve enhanced secretion of insulin.Downloads
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