Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application

Authors

  • . Jasmin Universidade Federal do Rio de Janeiro (UFRJ) Author
  • Radovan Borojevic Faculdade de Medicina de Petrópolis/FASE, Author

DOI:

https://doi.org/10.22239/2317-269X.01067

Keywords:

Magnetic Nanoparticles, Cell Tacking, Stem Cells, Advanced Therapies, Nanomedicine

Abstract

Introduction: Regulation and introduction of new advanced cellular technologies in clinics requires better knowledge on the used cells. One of the major challenges is the difficulty to accurately determine the mechanisms of cell activities when submitted to advanced therapies. Objective: Understand, using the cell tracking methods, the tissue distribution and the molecular response of cells exposed to advanced therapies. Methods: This work was done as an integrated review of data collected in international data-bases and of legislations concerning the clinical use of nanoparticles. Results: Nanotechnology is a very useful tool for cell tracking in vivo, and several nanoparticles have been already approved for clinical use; they can be incorporated into cells and visualized by magnetic resonance imaging. Conclusions: The perspectives on the use of nanomedicines for cellular tracking in medical clinic are promising, requiring elaboration and approval of laws, guides and norms to orient the industrial sectors, regarding the nanomaterials characterization and potential risks to human and animal health, as well as to the environment.

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Author Biography

  • . Jasmin, Universidade Federal do Rio de Janeiro (UFRJ)

    Possui graduação em Ciências Biológicas pela Universidade Federal de Ouro Preto(2005), mestrado em Ciências Biológicas (Biofísica) pela Universidade Federal do Rio de Janeiro(2008), doutorado em Ciências pela Universidade Federal do Rio de Janeiro(2012), pós-doutorado pela Universidade Federal de Juiz de Fora(2013) e pós-doutorado pela Universidade Federal do Rio de Janeiro(2014). Atualmente é Revisor de periódico da International Journal of Nanomedicine, Revisor de periódico da Journal of Biomarkers in Drug Development, Revisor de periódico da Journal of Biomaterials Science, Polymer Edition, Revisor de periódico da Journal of Regenerative Medicine, Professor Adjunto da Universidade Federal do Rio de Janeiro, Revisor de periódico da Drug Design, Development and Therapy e Revisor de periódico da BioMed Research International. Tem experiência na área de Fisiologia, com ênfase em Fisiologia da Reprodução. Atuando principalmente nos seguintes temas:Doença de Chagas, Células-Tronco Mesenquimais, Rastreamento celular, Nanopartículas Magnéticas, Nanopartículas fluorescentes.

    CV: http://lattes.cnpq.br/6233173158475582

Published

2018-02-28

How to Cite

Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application. (2018). Health Surveillance under Debate: Society, Science & Technology , 6(1), 56-63. https://doi.org/10.22239/2317-269X.01067

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