Palatability studies of oral formulations: an overview about drug acceptance in pediatrics
DOI:
https://doi.org/10.22239/2317-269X.01011Keywords:
Pharmaceutical Preparations, Medication Adherence, Children, Sensory Analysis, Taste AcceptabilityAbstract
Introduction: Children often reject non-palatable medications. Pediatric formulations contain sweeteners and flavorings to mask the unpleasant taste and avoid problems in administration and adherence. Taste assessment is an essential part of the development of oral liquid medicines. Objective: This paper aims to contextualize assessment and influence of palatability on the acceptance of pediatric medicines. Method: Narrative review of the literature through the electronic databases PubMed and Google Scholar. Articles related to the development of formulations, use of electronic tongue, and abstracts without access to the complete work were not considered. Results: Flavor is considered one of the main determinants for medications’ adhesion in pediatrics. Access to palatable and safe pediatric formulations can have a substantial effect on infant morbidity. Adults and children appreciate flavors in different ways, so sensory testing with children is the most reliable method regarding formulations for this population. Studies of sensory perception and acceptance of medications already used by children may be ethically feasible, given the concerns about research with children. Conclusions: Sensory analyzes should be carried out whenever there is a new formulation to be introduced on the market, addressed to different age brackets and cultural contexts, in order to assess the product’s acceptabilityDownloads
Downloads
Published
Issue
Section
License
Copyright (c) 2018 Health Surveillance under Debate: Society, Science & Technology (Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnología) – “Visa em Debate”
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
COPYRIGHT ALLOWANCE The author (s) hereinafter designated as the ASSIGNOR hereby assign and transfer, free of charge, the ownership of the copyrights related to this ARTICLE to the Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) – Visa em Debate, represented by FUNDAÇÃO OSWALDO CRUZ, established at Av. Brasil, nº 4365, Manguinhos, Rio de Janeiro, RJ, Brazil, CEP 21045-900, under the conditions set out below: (a) The terms and conditions set forth in this Agreement shall apply to the following: 1. The ASSIGNOR declares that they s(he) is (are) the author (s) and owner (s) of the copyrighted property of the ARTICLE submitted. 2. The ASSIGNOR declares that the ARTICLE does not infringe the copyrights and / or other property rights of third parties, that the disclosure of images (if any) has been authorized and that they s(he) assume(s) full moral and / or property liability for its content, before third parties. 3. THE ASSIGNOR assigns and transfers all copyrights relating to the ARTICLE to the ASSIGNEE, especially the rights of editing, publication, translation into another language and reproduction by any process or technique. The ASSIGNEE becomes the exclusive owner of the rights related to the ARTICLE, and any reproduction, totally or partially, is prohibited in any other means of publicity, printed or electronic, without prior written authorization from the ASSIGNEE. 4. The assignment is free and, therefore, there will be no remuneration for the use of the ARTICLE by the ASSIGNEE.